{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 1194
    },
    {
      "term": "Vomiting",
      "count": 569
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 423
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 314
    },
    {
      "term": "Death by euthanasia",
      "count": 286
    },
    {
      "term": "Anorexia",
      "count": 279
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 268
    },
    {
      "term": "Diarrhoea",
      "count": 253
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 237
    },
    {
      "term": "Cough",
      "count": 225
    },
    {
      "term": "Death",
      "count": 212
    },
    {
      "term": "Leucocytosis NOS",
      "count": 210
    },
    {
      "term": "Fever",
      "count": 201
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 200
    },
    {
      "term": "Weight loss",
      "count": 197
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 195
    },
    {
      "term": "Anaemia NOS",
      "count": 189
    },
    {
      "term": "Not eating",
      "count": 187
    },
    {
      "term": "Thrombocytopenia",
      "count": 165
    },
    {
      "term": "Decreased appetite",
      "count": 164
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 163
    },
    {
      "term": "Seizure NOS",
      "count": 156
    },
    {
      "term": "Neutrophilia",
      "count": 155
    },
    {
      "term": "Panting",
      "count": 143
    },
    {
      "term": "Ataxia",
      "count": 138
    },
    {
      "term": "Elevated total bilirubin",
      "count": 125
    },
    {
      "term": "Pain NOS",
      "count": 120
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 117
    },
    {
      "term": "Emesis",
      "count": 115
    },
    {
      "term": "INEFFECTIVE, HEARTWORM ADULTS",
      "count": 113
    },
    {
      "term": "Pale mucous membrane",
      "count": 108
    },
    {
      "term": "Elevated liver enzymes",
      "count": 107
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 106
    },
    {
      "term": "Low platelet count",
      "count": 106
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 100
    },
    {
      "term": "Monocytosis",
      "count": 96
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 92
    },
    {
      "term": "Polydipsia",
      "count": 85
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 83
    },
    {
      "term": "Elevated creatinine",
      "count": 80
    },
    {
      "term": "Polyuria",
      "count": 80
    },
    {
      "term": "Hyperphosphataemia",
      "count": 76
    },
    {
      "term": "Weakness",
      "count": 76
    },
    {
      "term": "Proteinuria",
      "count": 73
    },
    {
      "term": "Emesis (multiple)",
      "count": 71
    },
    {
      "term": "Intentional misuse",
      "count": 70
    },
    {
      "term": "Shaking",
      "count": 70
    },
    {
      "term": "Dehydration",
      "count": 69
    },
    {
      "term": "Lameness",
      "count": 69
    },
    {
      "term": "Tachycardia",
      "count": 68
    },
    {
      "term": "Medication error NOS",
      "count": 67
    },
    {
      "term": "Immune mediated haemolytic anaemia",
      "count": 66
    },
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 65
    },
    {
      "term": "Inappetence",
      "count": 65
    },
    {
      "term": "Walking difficulty",
      "count": 64
    },
    {
      "term": "Lymphopenia",
      "count": 61
    },
    {
      "term": "Decreased packed cell volume (PCV)",
      "count": 60
    },
    {
      "term": "Abnormal cytology",
      "count": 58
    },
    {
      "term": "Drooling",
      "count": 57
    },
    {
      "term": "Pruritus",
      "count": 57
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 56
    },
    {
      "term": "Injection site swelling",
      "count": 56
    },
    {
      "term": "Lack of efficacy (bacteria) - Borrelia",
      "count": 56
    },
    {
      "term": "Decreased red blood cell count",
      "count": 55
    },
    {
      "term": "Leucopenia NOS",
      "count": 55
    },
    {
      "term": "Weight gain",
      "count": 55
    },
    {
      "term": "Vocalisation",
      "count": 54
    },
    {
      "term": "Elevated globulins",
      "count": 53
    },
    {
      "term": "Hypersalivation",
      "count": 52
    },
    {
      "term": "Bloody diarrhoea",
      "count": 51
    },
    {
      "term": "Hyperglycaemia",
      "count": 50
    },
    {
      "term": "Loose stool",
      "count": 50
    },
    {
      "term": "Urinary tract infection",
      "count": 50
    },
    {
      "term": "Tremor",
      "count": 47
    },
    {
      "term": "Urinary incontinence",
      "count": 47
    },
    {
      "term": "Haematuria",
      "count": 46
    },
    {
      "term": "Icterus",
      "count": 46
    },
    {
      "term": "Inappropriate urination",
      "count": 46
    },
    {
      "term": "Dyspnoea",
      "count": 45
    },
    {
      "term": "Laboured breathing",
      "count": 45
    },
    {
      "term": "Anaphylaxis",
      "count": 44
    },
    {
      "term": "Immune mediated thrombocytopenia",
      "count": 44
    },
    {
      "term": "Lateral recumbency",
      "count": 44
    },
    {
      "term": "Nasal discharge",
      "count": 44
    },
    {
      "term": "Not drinking",
      "count": 44
    },
    {
      "term": "Underdose",
      "count": 44
    },
    {
      "term": "Elevated renal parameters",
      "count": 43
    },
    {
      "term": "Hypoproteinaemia",
      "count": 43
    },
    {
      "term": "Restlessness",
      "count": 43
    },
    {
      "term": "Abnormal breathing",
      "count": 42
    },
    {
      "term": "Ocular discharge",
      "count": 42
    },
    {
      "term": "Injection site pain",
      "count": 41
    },
    {
      "term": "Overdose",
      "count": 41
    },
    {
      "term": "Reluctant to move",
      "count": 41
    },
    {
      "term": "Breathing difficulty",
      "count": 40
    },
    {
      "term": "Elevated amylase",
      "count": 40
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 40
    },
    {
      "term": "Decreased haemoglobin",
      "count": 39
    },
    {
      "term": "Unable to stand",
      "count": 39
    },
    {
      "term": "Urine abnormalities NOS",
      "count": 39
    }
  ]
}