{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Lack of efficacy - NOS",
      "count": 823
    },
    {
      "term": "INEFFECTIVE, SEDATION",
      "count": 762
    },
    {
      "term": "Bradycardia",
      "count": 594
    },
    {
      "term": "Vomiting",
      "count": 482
    },
    {
      "term": "Death",
      "count": 444
    },
    {
      "term": "Cardiac arrest",
      "count": 302
    },
    {
      "term": "Diarrhoea",
      "count": 275
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 261
    },
    {
      "term": "Sedation",
      "count": 233
    },
    {
      "term": "Sedation prolonged",
      "count": 218
    },
    {
      "term": "Seizure NOS",
      "count": 216
    },
    {
      "term": "Anorexia",
      "count": 215
    },
    {
      "term": "Injection site swelling",
      "count": 215
    },
    {
      "term": "Underdose",
      "count": 185
    },
    {
      "term": "Overdose",
      "count": 180
    },
    {
      "term": "Apnoea",
      "count": 179
    },
    {
      "term": "Death by euthanasia",
      "count": 174
    },
    {
      "term": "Pale mucous membrane",
      "count": 174
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 168
    },
    {
      "term": "Tachycardia",
      "count": 167
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 166
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 151
    },
    {
      "term": "Not eating",
      "count": 150
    },
    {
      "term": "Panting",
      "count": 146
    },
    {
      "term": "INEFFECTIVE, REVERSAL",
      "count": 142
    },
    {
      "term": "Pain NOS",
      "count": 142
    },
    {
      "term": "Decreased appetite",
      "count": 137
    },
    {
      "term": "Bloody diarrhoea",
      "count": 130
    },
    {
      "term": "Fever",
      "count": 130
    },
    {
      "term": "Vocalisation",
      "count": 129
    },
    {
      "term": "Weight loss",
      "count": 111
    },
    {
      "term": "Ataxia",
      "count": 109
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 104
    },
    {
      "term": "Elevated total bilirubin",
      "count": 104
    },
    {
      "term": "Leucocytosis NOS",
      "count": 102
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 101
    },
    {
      "term": "Hypothermia",
      "count": 100
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 99
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 98
    },
    {
      "term": "Accidental exposure",
      "count": 97
    },
    {
      "term": "Hypersalivation",
      "count": 96
    },
    {
      "term": "Recovery prolonged",
      "count": 95
    },
    {
      "term": "Cyanosis",
      "count": 94
    },
    {
      "term": "Hypotension",
      "count": 94
    },
    {
      "term": "Arrhythmia",
      "count": 92
    },
    {
      "term": "Respiratory arrest",
      "count": 91
    },
    {
      "term": "Elevated creatinine",
      "count": 89
    },
    {
      "term": "Decreased heart rate",
      "count": 83
    },
    {
      "term": "Dehydration",
      "count": 83
    },
    {
      "term": "Convulsion",
      "count": 82
    },
    {
      "term": "Wound",
      "count": 82
    },
    {
      "term": "Anaphylaxis",
      "count": 80
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 79
    },
    {
      "term": "Depression",
      "count": 79
    },
    {
      "term": "Injection site pain",
      "count": 78
    },
    {
      "term": "Neutrophilia",
      "count": 75
    },
    {
      "term": "Swollen limb",
      "count": 71
    },
    {
      "term": "Drug administration error",
      "count": 70
    },
    {
      "term": "Swelling NOS",
      "count": 68
    },
    {
      "term": "Hyperphosphataemia",
      "count": 66
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 65
    },
    {
      "term": "Intentional misuse",
      "count": 64
    },
    {
      "term": "Hyperthermia",
      "count": 62
    },
    {
      "term": "Drooling",
      "count": 60
    },
    {
      "term": "Inappetence",
      "count": 60
    },
    {
      "term": "Lameness",
      "count": 60
    },
    {
      "term": "Twitching",
      "count": 60
    },
    {
      "term": "Hyperglycaemia",
      "count": 59
    },
    {
      "term": "Anxiety",
      "count": 57
    },
    {
      "term": "Emesis",
      "count": 57
    },
    {
      "term": "Bruising",
      "count": 56
    },
    {
      "term": "Heart block NOS",
      "count": 56
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 56
    },
    {
      "term": "Injection site bleeding",
      "count": 56
    },
    {
      "term": "Injection site necrosis",
      "count": 56
    },
    {
      "term": "Locking Mechanism Abnormal",
      "count": 56
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 55
    },
    {
      "term": "Icterus",
      "count": 55
    },
    {
      "term": "Shaking",
      "count": 55
    },
    {
      "term": "Thrombocytopenia",
      "count": 55
    },
    {
      "term": "Polydipsia",
      "count": 53
    },
    {
      "term": "Weakness",
      "count": 53
    },
    {
      "term": "Dyspnoea",
      "count": 52
    },
    {
      "term": "Urinary incontinence",
      "count": 52
    },
    {
      "term": "Anaemia NOS",
      "count": 51
    },
    {
      "term": "Injection site skin discolouration",
      "count": 50
    },
    {
      "term": "Licking at injection site",
      "count": 50
    },
    {
      "term": "Trembling",
      "count": 50
    },
    {
      "term": "Emesis (multiple)",
      "count": 48
    },
    {
      "term": "Injection site bruising",
      "count": 48
    },
    {
      "term": "Monocytosis",
      "count": 48
    },
    {
      "term": "Reluctant to move",
      "count": 48
    },
    {
      "term": "Elevated liver enzymes",
      "count": 47
    },
    {
      "term": "Tachypnoea",
      "count": 47
    },
    {
      "term": "Lack of efficacy (neoplasia, partial remission)",
      "count": 45
    },
    {
      "term": "Not drinking",
      "count": 45
    },
    {
      "term": "Premature ventricular contractions",
      "count": 45
    },
    {
      "term": "Limb non-weight bearing",
      "count": 44
    },
    {
      "term": "Local swelling (not application site)",
      "count": 44
    },
    {
      "term": "Lymphopenia",
      "count": 44
    }
  ]
}