{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Death",
      "count": 359
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 276
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 234
    },
    {
      "term": "Hypersalivation",
      "count": 183
    },
    {
      "term": "Not eating",
      "count": 173
    },
    {
      "term": "Dilated pupils",
      "count": 171
    },
    {
      "term": "Cardiac arrest",
      "count": 169
    },
    {
      "term": "INEFFECTIVE, SEDATION",
      "count": 165
    },
    {
      "term": "Hyperactivity",
      "count": 154
    },
    {
      "term": "Anorexia",
      "count": 147
    },
    {
      "term": "Vomiting",
      "count": 145
    },
    {
      "term": "Fever",
      "count": 144
    },
    {
      "term": "Hyperthermia",
      "count": 131
    },
    {
      "term": "Hypothermia",
      "count": 128
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 122
    },
    {
      "term": "Death by euthanasia",
      "count": 117
    },
    {
      "term": "Bradycardia",
      "count": 116
    },
    {
      "term": "Dysphoria",
      "count": 114
    },
    {
      "term": "Ataxia",
      "count": 111
    },
    {
      "term": "Sedation prolonged",
      "count": 101
    },
    {
      "term": "Vocalisation",
      "count": 99
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 98
    },
    {
      "term": "Seizure NOS",
      "count": 91
    },
    {
      "term": "Elevated temperature",
      "count": 87
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 79
    },
    {
      "term": "Apnoea",
      "count": 79
    },
    {
      "term": "Recovery prolonged",
      "count": 76
    },
    {
      "term": "Agitation",
      "count": 75
    },
    {
      "term": "Tachycardia",
      "count": 75
    },
    {
      "term": "Not sleeping",
      "count": 74
    },
    {
      "term": "Cyanosis",
      "count": 73
    },
    {
      "term": "Hiding",
      "count": 72
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 72
    },
    {
      "term": "Panting",
      "count": 71
    },
    {
      "term": "Dehydration",
      "count": 70
    },
    {
      "term": "Decreased appetite",
      "count": 69
    },
    {
      "term": "Weight loss",
      "count": 65
    },
    {
      "term": "Underdose",
      "count": 64
    },
    {
      "term": "Tachypnoea",
      "count": 63
    },
    {
      "term": "Respiratory arrest",
      "count": 61
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 59
    },
    {
      "term": "Elevated creatinine",
      "count": 59
    },
    {
      "term": "Diarrhoea",
      "count": 58
    },
    {
      "term": "Drooling",
      "count": 57
    },
    {
      "term": "Pale mucous membrane",
      "count": 56
    },
    {
      "term": "Anaemia NOS",
      "count": 55
    },
    {
      "term": "Intentional misuse",
      "count": 55
    },
    {
      "term": "Twitching",
      "count": 55
    },
    {
      "term": "Hypotension",
      "count": 53
    },
    {
      "term": "Sedation",
      "count": 53
    },
    {
      "term": "Depression",
      "count": 52
    },
    {
      "term": "Hyperglycaemia",
      "count": 52
    },
    {
      "term": "Not drinking",
      "count": 51
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 48
    },
    {
      "term": "Restlessness",
      "count": 48
    },
    {
      "term": "Mydriasis",
      "count": 46
    },
    {
      "term": "Hyperphosphataemia",
      "count": 44
    },
    {
      "term": "Application site hair loss",
      "count": 43
    },
    {
      "term": "Lateral recumbency",
      "count": 40
    },
    {
      "term": "Aggression",
      "count": 39
    },
    {
      "term": "Dyspnoea",
      "count": 39
    },
    {
      "term": "Open mouth breathing",
      "count": 37
    },
    {
      "term": "Application site alopecia",
      "count": 35
    },
    {
      "term": "Pacing",
      "count": 35
    },
    {
      "term": "Pain NOS",
      "count": 35
    },
    {
      "term": "Disorientation",
      "count": 34
    },
    {
      "term": "Pulmonary oedema",
      "count": 33
    },
    {
      "term": "Constipation",
      "count": 32
    },
    {
      "term": "Respiratory distress",
      "count": 31
    },
    {
      "term": "Decreased body temperature",
      "count": 29
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 28
    },
    {
      "term": "Adipsia",
      "count": 28
    },
    {
      "term": "Anisocoria",
      "count": 28
    },
    {
      "term": "Blindness",
      "count": 28
    },
    {
      "term": "Elevated total bilirubin",
      "count": 27
    },
    {
      "term": "Anxiety",
      "count": 26
    },
    {
      "term": "Inappetence",
      "count": 26
    },
    {
      "term": "Low blood pressure",
      "count": 26
    },
    {
      "term": "Anaphylaxis",
      "count": 25
    },
    {
      "term": "Arrhythmia",
      "count": 25
    },
    {
      "term": "Cardiac disorder NOS",
      "count": 25
    },
    {
      "term": "Proteinuria",
      "count": 25
    },
    {
      "term": "Unresponsive to stimuli",
      "count": 25
    },
    {
      "term": "Emesis",
      "count": 24
    },
    {
      "term": "Leucocytosis NOS",
      "count": 24
    },
    {
      "term": "Neutrophilia",
      "count": 24
    },
    {
      "term": "Respiratory tract disorder NOS",
      "count": 24
    },
    {
      "term": "Hyperexcitation",
      "count": 23
    },
    {
      "term": "Nausea",
      "count": 23
    },
    {
      "term": "Reluctant to move",
      "count": 23
    },
    {
      "term": "Weakness",
      "count": 23
    },
    {
      "term": "Elevated symmetrical dimethylarginine (SDMA)",
      "count": 22
    },
    {
      "term": "Hypoglycaemia",
      "count": 22
    },
    {
      "term": "Necropsy performed",
      "count": 22
    },
    {
      "term": "Wobbliness",
      "count": 22
    },
    {
      "term": "Abnormal menace reflex test",
      "count": 21
    },
    {
      "term": "Convulsion",
      "count": 21
    },
    {
      "term": "INEFFECTIVE, REVERSAL",
      "count": 21
    },
    {
      "term": "Increased respiratory rate",
      "count": 21
    },
    {
      "term": "Nystagmus",
      "count": 21
    }
  ]
}