{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Seizure NOS",
      "count": 84
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 74
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 46
    },
    {
      "term": "Ataxia",
      "count": 43
    },
    {
      "term": "Vomiting",
      "count": 33
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 31
    },
    {
      "term": "INEFFECTIVE, SEIZURES",
      "count": 23
    },
    {
      "term": "Diarrhoea",
      "count": 21
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 17
    },
    {
      "term": "Limb weakness",
      "count": 17
    },
    {
      "term": "Cough",
      "count": 16
    },
    {
      "term": "Death by euthanasia",
      "count": 16
    },
    {
      "term": "Emesis",
      "count": 16
    },
    {
      "term": "Increased seizure frequency",
      "count": 15
    },
    {
      "term": "Anorexia",
      "count": 14
    },
    {
      "term": "Not eating",
      "count": 14
    },
    {
      "term": "Weight gain",
      "count": 14
    },
    {
      "term": "Death",
      "count": 13
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 13
    },
    {
      "term": "Polydipsia",
      "count": 13
    },
    {
      "term": "Weakness",
      "count": 12
    },
    {
      "term": "Emesis (multiple)",
      "count": 11
    },
    {
      "term": "Hyperkalaemia",
      "count": 11
    },
    {
      "term": "Hyperchloraemia",
      "count": 9
    },
    {
      "term": "Overdose",
      "count": 9
    },
    {
      "term": "Decreased appetite",
      "count": 8
    },
    {
      "term": "Hind limb ataxia",
      "count": 8
    },
    {
      "term": "Increased appetite",
      "count": 8
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 8
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 8
    },
    {
      "term": "Pacing",
      "count": 8
    },
    {
      "term": "Pancreatitis",
      "count": 8
    },
    {
      "term": "Panting",
      "count": 8
    },
    {
      "term": "Polyuria",
      "count": 8
    },
    {
      "term": "Walking difficulty",
      "count": 8
    },
    {
      "term": "Agitation",
      "count": 7
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 7
    },
    {
      "term": "Dehydration",
      "count": 7
    },
    {
      "term": "Unable to stand",
      "count": 7
    },
    {
      "term": "Underdose",
      "count": 7
    },
    {
      "term": "Urinary tract infection",
      "count": 7
    },
    {
      "term": "Disorientation",
      "count": 6
    },
    {
      "term": "Elevated liver enzymes",
      "count": 6
    },
    {
      "term": "Falling",
      "count": 6
    },
    {
      "term": "Hypernatremia",
      "count": 6
    },
    {
      "term": "Leucocytosis NOS",
      "count": 6
    },
    {
      "term": "Restlessness",
      "count": 6
    },
    {
      "term": "Weight loss",
      "count": 6
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 5
    },
    {
      "term": "Accidental exposure",
      "count": 5
    },
    {
      "term": "Anaemia NOS",
      "count": 5
    },
    {
      "term": "Anxiety",
      "count": 5
    },
    {
      "term": "Collapse of leg",
      "count": 5
    },
    {
      "term": "Constipation",
      "count": 5
    },
    {
      "term": "Electrolyte disorder",
      "count": 5
    },
    {
      "term": "Elevated creatinine",
      "count": 5
    },
    {
      "term": "Fever",
      "count": 5
    },
    {
      "term": "Inappropriate urination",
      "count": 5
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 5
    },
    {
      "term": "Pruritus",
      "count": 5
    },
    {
      "term": "Thrombocytosis",
      "count": 5
    },
    {
      "term": "Urinary incontinence",
      "count": 5
    },
    {
      "term": "Decreased urine concentration",
      "count": 4
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 4
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 4
    },
    {
      "term": "Excessive thirst",
      "count": 4
    },
    {
      "term": "Gagging",
      "count": 4
    },
    {
      "term": "Hind limb paresis",
      "count": 4
    },
    {
      "term": "Hyperphosphataemia",
      "count": 4
    },
    {
      "term": "Hyponatremia",
      "count": 4
    },
    {
      "term": "Hypothyroidism",
      "count": 4
    },
    {
      "term": "INEFFECTIVE, LOSS OF EFFECT",
      "count": 4
    },
    {
      "term": "Muscle weakness NOS",
      "count": 4
    },
    {
      "term": "Nasal discharge",
      "count": 4
    },
    {
      "term": "Neutrophilia",
      "count": 4
    },
    {
      "term": "Polyphagia",
      "count": 4
    },
    {
      "term": "Reluctant to move",
      "count": 4
    },
    {
      "term": "Shaking",
      "count": 4
    },
    {
      "term": "Stumbling gait",
      "count": 4
    },
    {
      "term": "Tablets, Abnormal",
      "count": 4
    },
    {
      "term": "Trembling",
      "count": 4
    },
    {
      "term": "Tremor",
      "count": 4
    },
    {
      "term": "Uncoded sign",
      "count": 4
    },
    {
      "term": "Urine abnormalities NOS",
      "count": 4
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 3
    },
    {
      "term": "Bloody diarrhoea",
      "count": 3
    },
    {
      "term": "Breathing difficulty",
      "count": 3
    },
    {
      "term": "Collapse NOS (see also Cardio-vascular and Neurological disorders)",
      "count": 3
    },
    {
      "term": "Convulsion",
      "count": 3
    },
    {
      "term": "Decreased activity",
      "count": 3
    },
    {
      "term": "Dermatitis",
      "count": 3
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 3
    },
    {
      "term": "Distension of abdomen",
      "count": 3
    },
    {
      "term": "Dyspnoea",
      "count": 3
    },
    {
      "term": "Elevated temperature",
      "count": 3
    },
    {
      "term": "Elevated total bilirubin",
      "count": 3
    },
    {
      "term": "Epileptic seizure",
      "count": 3
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 3
    },
    {
      "term": "Flatulence",
      "count": 3
    },
    {
      "term": "Focal seizure",
      "count": 3
    }
  ]
}