{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Ketosis",
      "count": 1470
    },
    {
      "term": "Weight loss",
      "count": 1017
    },
    {
      "term": "Hyperglycaemia",
      "count": 847
    },
    {
      "term": "Diarrhoea",
      "count": 722
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 549
    },
    {
      "term": "Vomiting",
      "count": 427
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 421
    },
    {
      "term": "Hypoglycaemia",
      "count": 402
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 388
    },
    {
      "term": "Glucosuria",
      "count": 346
    },
    {
      "term": "Not eating",
      "count": 332
    },
    {
      "term": "Diabetic ketoacidosis",
      "count": 267
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 246
    },
    {
      "term": "Weight gain",
      "count": 245
    },
    {
      "term": "Death by euthanasia",
      "count": 243
    },
    {
      "term": "Dehydration",
      "count": 228
    },
    {
      "term": "Polyuria",
      "count": 225
    },
    {
      "term": "Decreased appetite",
      "count": 219
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 201
    },
    {
      "term": "Polydipsia",
      "count": 198
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 193
    },
    {
      "term": "Elevated creatinine",
      "count": 162
    },
    {
      "term": "Anorexia",
      "count": 148
    },
    {
      "term": "Hypokalaemia",
      "count": 147
    },
    {
      "term": "Loose stool",
      "count": 143
    },
    {
      "term": "Elevated symmetrical dimethylarginine (SDMA)",
      "count": 126
    },
    {
      "term": "Ketonuria",
      "count": 122
    },
    {
      "term": "Elevated cholesterol (total)",
      "count": 119
    },
    {
      "term": "Elevated betahydroxybutyrate (BHP)",
      "count": 118
    },
    {
      "term": "Urinary tract infection",
      "count": 117
    },
    {
      "term": "Elevated betahydroxybutyrate (BHBA)",
      "count": 114
    },
    {
      "term": "High pancreatic-specific lipase",
      "count": 100
    },
    {
      "term": "Elevated total bilirubin",
      "count": 95
    },
    {
      "term": "Hypercalcaemia",
      "count": 92
    },
    {
      "term": "Unwell",
      "count": 92
    },
    {
      "term": "Inappropriate urination",
      "count": 90
    },
    {
      "term": "Proteinuria",
      "count": 88
    },
    {
      "term": "Hiding",
      "count": 85
    },
    {
      "term": "Urine abnormalities NOS",
      "count": 83
    },
    {
      "term": "Hypochloraemia",
      "count": 73
    },
    {
      "term": "Soft stool",
      "count": 73
    },
    {
      "term": "Elevated globulins",
      "count": 70
    },
    {
      "term": "UNPALATABLE",
      "count": 70
    },
    {
      "term": "Leucocytosis NOS",
      "count": 68
    },
    {
      "term": "Hyperphosphataemia",
      "count": 67
    },
    {
      "term": "Elevated fructosamine",
      "count": 66
    },
    {
      "term": "Increased appetite",
      "count": 64
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 63
    },
    {
      "term": "Death",
      "count": 63
    },
    {
      "term": "Pancreatitis NOS",
      "count": 60
    },
    {
      "term": "Hyperalbuminaemia",
      "count": 56
    },
    {
      "term": "Malaise",
      "count": 55
    },
    {
      "term": "Inappetence",
      "count": 54
    },
    {
      "term": "Not drinking",
      "count": 54
    },
    {
      "term": "Emesis (multiple)",
      "count": 51
    },
    {
      "term": "Blood in urine",
      "count": 50
    },
    {
      "term": "Anaemia NOS",
      "count": 49
    },
    {
      "term": "Neutrophilia",
      "count": 48
    },
    {
      "term": "Weakness",
      "count": 48
    },
    {
      "term": "Elevated triglyceride",
      "count": 47
    },
    {
      "term": "Hyperproteinaemia",
      "count": 47
    },
    {
      "term": "Decreased haematocrit",
      "count": 46
    },
    {
      "term": "Polyphagia",
      "count": 46
    },
    {
      "term": "Drinking a lot",
      "count": 45
    },
    {
      "term": "Elevated aspartate aminotransferase (AST)",
      "count": 44
    },
    {
      "term": "Azotaemia",
      "count": 43
    },
    {
      "term": "Constipation",
      "count": 43
    },
    {
      "term": "Renal disorder NOS",
      "count": 42
    },
    {
      "term": "Distress",
      "count": 41
    },
    {
      "term": "Elevated lipase",
      "count": 38
    },
    {
      "term": "Not himself/herself",
      "count": 36
    },
    {
      "term": "Hyponatremia",
      "count": 35
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 33
    },
    {
      "term": "Heart murmur",
      "count": 31
    },
    {
      "term": "Inappropriate defecation",
      "count": 31
    },
    {
      "term": "Vocalisation",
      "count": 31
    },
    {
      "term": "Appetite loss",
      "count": 30
    },
    {
      "term": "Haematuria",
      "count": 30
    },
    {
      "term": "Weight fluctuation",
      "count": 30
    },
    {
      "term": "Fever",
      "count": 29
    },
    {
      "term": "Hypothermia",
      "count": 29
    },
    {
      "term": "Muscle wasting",
      "count": 29
    },
    {
      "term": "Unclassifiable adverse event",
      "count": 29
    },
    {
      "term": "Hypernatremia",
      "count": 28
    },
    {
      "term": "Icterus",
      "count": 28
    },
    {
      "term": "Monocytosis",
      "count": 28
    },
    {
      "term": "Ataxia",
      "count": 27
    },
    {
      "term": "Decreased drinking",
      "count": 27
    },
    {
      "term": "Loss of condition score",
      "count": 27
    },
    {
      "term": "Depression",
      "count": 26
    },
    {
      "term": "Frequent urination",
      "count": 26
    },
    {
      "term": "High ionized calcium (Ca; Hypercalcemia, ionized)",
      "count": 26
    },
    {
      "term": "Hypophosphataemia",
      "count": 26
    },
    {
      "term": "Pancreatitis",
      "count": 26
    },
    {
      "term": "Aggression",
      "count": 25
    },
    {
      "term": "Elevated amylase",
      "count": 25
    },
    {
      "term": "Sleepiness - systemic disorder",
      "count": 25
    },
    {
      "term": "Product defect, product difficult to use/handle (see also 'Drug device difficult to use/handle')",
      "count": 24
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 23
    },
    {
      "term": "Eosinophilia",
      "count": 22
    }
  ]
}