{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Deafness",
      "count": 1427
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 1260
    },
    {
      "term": "Vomiting",
      "count": 254
    },
    {
      "term": "Partial deafness",
      "count": 246
    },
    {
      "term": "Ear discharge",
      "count": 187
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 180
    },
    {
      "term": "Loss of hearing",
      "count": 176
    },
    {
      "term": "Diarrhoea",
      "count": 140
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 125
    },
    {
      "term": "Head shake - ear disorder",
      "count": 121
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 115
    },
    {
      "term": "Head tilt - ear disorder",
      "count": 97
    },
    {
      "term": "Emesis",
      "count": 95
    },
    {
      "term": "Hearing decreased",
      "count": 92
    },
    {
      "term": "Ear pain",
      "count": 85
    },
    {
      "term": "CULTURE/TITER DATA ABNORMAL",
      "count": 84
    },
    {
      "term": "Not eating",
      "count": 83
    },
    {
      "term": "Anorexia",
      "count": 82
    },
    {
      "term": "Other ear disorder NOS",
      "count": 82
    },
    {
      "term": "Corneal ulcer",
      "count": 81
    },
    {
      "term": "Ear infection NOS",
      "count": 81
    },
    {
      "term": "Ataxia",
      "count": 79
    },
    {
      "term": "Death by euthanasia",
      "count": 74
    },
    {
      "term": "Decreased appetite",
      "count": 71
    },
    {
      "term": "External ear disorder NOS",
      "count": 71
    },
    {
      "term": "Impaired hearing",
      "count": 69
    },
    {
      "term": "Otitis externa",
      "count": 63
    },
    {
      "term": "Depression",
      "count": 59
    },
    {
      "term": "Weight loss",
      "count": 59
    },
    {
      "term": "Ocular discharge",
      "count": 58
    },
    {
      "term": "Accidental exposure",
      "count": 57
    },
    {
      "term": "Pinnal erythema",
      "count": 57
    },
    {
      "term": "Seizure NOS",
      "count": 56
    },
    {
      "term": "Polydipsia",
      "count": 54
    },
    {
      "term": "Polyuria",
      "count": 54
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 50
    },
    {
      "term": "Death",
      "count": 46
    },
    {
      "term": "PR-EAR(S), LESION(S)",
      "count": 46
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 44
    },
    {
      "term": "Leucocytosis NOS",
      "count": 44
    },
    {
      "term": "Pruritus",
      "count": 44
    },
    {
      "term": "Vocalisation",
      "count": 44
    },
    {
      "term": "Vestibular disorder NOS",
      "count": 43
    },
    {
      "term": "Nystagmus",
      "count": 42
    },
    {
      "term": "Panting",
      "count": 42
    },
    {
      "term": "Temporary deafness",
      "count": 42
    },
    {
      "term": "Application site erythema",
      "count": 41
    },
    {
      "term": "Partial lack of efficacy",
      "count": 41
    },
    {
      "term": "Restlessness",
      "count": 40
    },
    {
      "term": "Pinnal irritation",
      "count": 39
    },
    {
      "term": "Abnormal cytology",
      "count": 38
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 37
    },
    {
      "term": "Nasal discharge",
      "count": 37
    },
    {
      "term": "Shaking",
      "count": 36
    },
    {
      "term": "Otorrhoea",
      "count": 35
    },
    {
      "term": "Neutrophilia",
      "count": 34
    },
    {
      "term": "Application site inflammation",
      "count": 33
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 33
    },
    {
      "term": "Keratoconjunctivitis sicca",
      "count": 33
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 32
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 32
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 31
    },
    {
      "term": "Dry eye",
      "count": 31
    },
    {
      "term": "Elevated liver enzymes",
      "count": 30
    },
    {
      "term": "Fever",
      "count": 30
    },
    {
      "term": "Pain NOS",
      "count": 30
    },
    {
      "term": "Schirmer tear test",
      "count": 30
    },
    {
      "term": "Scratching",
      "count": 30
    },
    {
      "term": "Squinting",
      "count": 30
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 28
    },
    {
      "term": "Skin lesion NOS",
      "count": 28
    },
    {
      "term": "Crust",
      "count": 27
    },
    {
      "term": "Deafness NOS",
      "count": 27
    },
    {
      "term": "Loose stool",
      "count": 27
    },
    {
      "term": "Hyperglycaemia",
      "count": 26
    },
    {
      "term": "Application site pain",
      "count": 25
    },
    {
      "term": "Conjunctivitis",
      "count": 25
    },
    {
      "term": "Corneal disorder NOS",
      "count": 25
    },
    {
      "term": "Anxiety",
      "count": 24
    },
    {
      "term": "Application site reddening",
      "count": 24
    },
    {
      "term": "Dehydration",
      "count": 24
    },
    {
      "term": "Ear canal erythema",
      "count": 24
    },
    {
      "term": "Facial paralysis",
      "count": 24
    },
    {
      "term": "Inappetence",
      "count": 24
    },
    {
      "term": "Blepharospasm",
      "count": 23
    },
    {
      "term": "Drooling",
      "count": 23
    },
    {
      "term": "Hearing affected",
      "count": 23
    },
    {
      "term": "Itching",
      "count": 22
    },
    {
      "term": "Skin disorders NOS",
      "count": 22
    },
    {
      "term": "Emesis (multiple)",
      "count": 21
    },
    {
      "term": "Eye pain",
      "count": 21
    },
    {
      "term": "Eye redness",
      "count": 21
    },
    {
      "term": "Low tear flow",
      "count": 21
    },
    {
      "term": "Anaemia NOS",
      "count": 20
    },
    {
      "term": "Drug administration duration too long",
      "count": 20
    },
    {
      "term": "Eye irritation",
      "count": 20
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 20
    },
    {
      "term": "Malaise",
      "count": 20
    },
    {
      "term": "Urticaria",
      "count": 20
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 19
    }
  ]
}