{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "INEFFECTIVE, REVERSAL",
      "count": 401
    },
    {
      "term": "Death",
      "count": 382
    },
    {
      "term": "Vomiting",
      "count": 274
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 248
    },
    {
      "term": "Bradycardia",
      "count": 207
    },
    {
      "term": "Diarrhoea",
      "count": 175
    },
    {
      "term": "Sedation prolonged",
      "count": 156
    },
    {
      "term": "Cardiac arrest",
      "count": 142
    },
    {
      "term": "Anorexia",
      "count": 136
    },
    {
      "term": "Injection site swelling",
      "count": 134
    },
    {
      "term": "Accidental exposure",
      "count": 118
    },
    {
      "term": "Tachycardia",
      "count": 118
    },
    {
      "term": "No sign",
      "count": 116
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 112
    },
    {
      "term": "Fever",
      "count": 111
    },
    {
      "term": "Hypersalivation",
      "count": 110
    },
    {
      "term": "Depression",
      "count": 105
    },
    {
      "term": "Death by euthanasia",
      "count": 101
    },
    {
      "term": "Convulsion",
      "count": 96
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 96
    },
    {
      "term": "Panting",
      "count": 91
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 89
    },
    {
      "term": "Bloody diarrhoea",
      "count": 86
    },
    {
      "term": "Pain NOS",
      "count": 85
    },
    {
      "term": "Ataxia",
      "count": 84
    },
    {
      "term": "Seizure NOS",
      "count": 83
    },
    {
      "term": "Underdose",
      "count": 82
    },
    {
      "term": "Not eating",
      "count": 77
    },
    {
      "term": "Apnoea",
      "count": 76
    },
    {
      "term": "Pale mucous membrane",
      "count": 75
    },
    {
      "term": "Vocalisation",
      "count": 72
    },
    {
      "term": "Weight loss",
      "count": 70
    },
    {
      "term": "Hypothermia",
      "count": 68
    },
    {
      "term": "Recovery prolonged",
      "count": 67
    },
    {
      "term": "Hyperactivity",
      "count": 65
    },
    {
      "term": "Trembling",
      "count": 63
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 62
    },
    {
      "term": "Wound",
      "count": 58
    },
    {
      "term": "Decreased appetite",
      "count": 57
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 56
    },
    {
      "term": "Restlessness",
      "count": 55
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 54
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 54
    },
    {
      "term": "Sedation",
      "count": 52
    },
    {
      "term": "Drug administration error",
      "count": 51
    },
    {
      "term": "Elevated total bilirubin",
      "count": 51
    },
    {
      "term": "Polypnoea",
      "count": 49
    },
    {
      "term": "Leucocytosis NOS",
      "count": 47
    },
    {
      "term": "Licking at injection site",
      "count": 46
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 45
    },
    {
      "term": "Cyanosis",
      "count": 42
    },
    {
      "term": "INEFFECTIVE, ANTIDOTE",
      "count": 42
    },
    {
      "term": "Swollen limb",
      "count": 42
    },
    {
      "term": "Swelling NOS",
      "count": 41
    },
    {
      "term": "Lameness",
      "count": 40
    },
    {
      "term": "Overdose",
      "count": 39
    },
    {
      "term": "Weakness",
      "count": 39
    },
    {
      "term": "Dehydration",
      "count": 38
    },
    {
      "term": "Hypotension",
      "count": 38
    },
    {
      "term": "Injection site bleeding",
      "count": 38
    },
    {
      "term": "Anaphylaxis",
      "count": 37
    },
    {
      "term": "Hyperglycaemia",
      "count": 37
    },
    {
      "term": "Incorrect route of drug administration",
      "count": 37
    },
    {
      "term": "Lack of efficacy (neoplasia, partial remission)",
      "count": 37
    },
    {
      "term": "Anaemia NOS",
      "count": 36
    },
    {
      "term": "Elevated creatinine",
      "count": 36
    },
    {
      "term": "Shaking",
      "count": 36
    },
    {
      "term": "Dyspnoea",
      "count": 35
    },
    {
      "term": "Injection site pain",
      "count": 35
    },
    {
      "term": "Injection site skin discolouration",
      "count": 35
    },
    {
      "term": "Collapse (see also 'Cardio-vascular' and 'Systemic disorders')",
      "count": 34
    },
    {
      "term": "Anxiety",
      "count": 33
    },
    {
      "term": "Injection site inflammation",
      "count": 33
    },
    {
      "term": "Arrhythmia",
      "count": 32
    },
    {
      "term": "Drooling",
      "count": 32
    },
    {
      "term": "Intentional misuse",
      "count": 32
    },
    {
      "term": "Tachypnoea",
      "count": 32
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 31
    },
    {
      "term": "Injection site reddening",
      "count": 31
    },
    {
      "term": "Injection site scab",
      "count": 31
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 30
    },
    {
      "term": "Injection site necrosis",
      "count": 30
    },
    {
      "term": "Injection site reaction NOS",
      "count": 30
    },
    {
      "term": "Twitching",
      "count": 30
    },
    {
      "term": "Elevated serum alkaline phosphatase (ALP)",
      "count": 29
    },
    {
      "term": "Emesis",
      "count": 29
    },
    {
      "term": "Hyperphosphataemia",
      "count": 29
    },
    {
      "term": "Injection site complication NOS",
      "count": 29
    },
    {
      "term": "Thrombocytopenia",
      "count": 29
    },
    {
      "term": "INEFFECTIVE, SEDATION",
      "count": 28
    },
    {
      "term": "Injection site bruising",
      "count": 28
    },
    {
      "term": "Lack of efficacy (neoplasia, no remission)",
      "count": 28
    },
    {
      "term": "Local swelling (not application site)",
      "count": 28
    },
    {
      "term": "Neutrophilia",
      "count": 28
    },
    {
      "term": "Decreased heart rate",
      "count": 27
    },
    {
      "term": "Loose stool",
      "count": 27
    },
    {
      "term": "Hypoglycaemia",
      "count": 26
    },
    {
      "term": "Hypoproteinaemia",
      "count": 26
    },
    {
      "term": "Limping",
      "count": 26
    },
    {
      "term": "Not drinking",
      "count": 26
    }
  ]
}