{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 15966
    },
    {
      "term": "Diarrhoea",
      "count": 6119
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 5703
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 4987
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 4527
    },
    {
      "term": "Seizure NOS",
      "count": 4402
    },
    {
      "term": "Lack of efficacy (bacteria) - Borrelia",
      "count": 3553
    },
    {
      "term": "Lack of efficacy (tick)",
      "count": 3389
    },
    {
      "term": "Skin disorders NOS",
      "count": 2625
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 2606
    },
    {
      "term": "Pruritus",
      "count": 2443
    },
    {
      "term": "Itching",
      "count": 2148
    },
    {
      "term": "Anorexia",
      "count": 1820
    },
    {
      "term": "Not eating",
      "count": 1805
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 1760
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 1632
    },
    {
      "term": "Panting",
      "count": 1534
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 1485
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 1422
    },
    {
      "term": "Shaking",
      "count": 1297
    },
    {
      "term": "Scratching",
      "count": 1247
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 1225
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 1194
    },
    {
      "term": "Ataxia",
      "count": 1179
    },
    {
      "term": "Death",
      "count": 1117
    },
    {
      "term": "Lack of efficacy (bacteria) - Anaplasma",
      "count": 1067
    },
    {
      "term": "Death by euthanasia",
      "count": 822
    },
    {
      "term": "Inappetence",
      "count": 808
    },
    {
      "term": "Emesis",
      "count": 803
    },
    {
      "term": "Decreased appetite",
      "count": 801
    },
    {
      "term": "Tremor",
      "count": 797
    },
    {
      "term": "Bloody diarrhoea",
      "count": 791
    },
    {
      "term": "Loose stool",
      "count": 778
    },
    {
      "term": "Lack of efficacy (bacteria) - Ehrlichia",
      "count": 769
    },
    {
      "term": "Erythema (for urticaria see Immune SOC)",
      "count": 768
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 765
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 755
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 697
    },
    {
      "term": "Vocalisation",
      "count": 640
    },
    {
      "term": "Restlessness",
      "count": 634
    },
    {
      "term": "Appetite loss",
      "count": 628
    },
    {
      "term": "Overdose",
      "count": 604
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 596
    },
    {
      "term": "Anxiety",
      "count": 576
    },
    {
      "term": "Drooling",
      "count": 566
    },
    {
      "term": "Emesis (multiple)",
      "count": 558
    },
    {
      "term": "Fever",
      "count": 550
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 545
    },
    {
      "term": "Weight loss",
      "count": 531
    },
    {
      "term": "Lack of efficacy (ectoparasite) - NOS",
      "count": 529
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 519
    },
    {
      "term": "Inappropriate urination",
      "count": 506
    },
    {
      "term": "Reddening of the skin",
      "count": 479
    },
    {
      "term": "Leucocytosis NOS",
      "count": 453
    },
    {
      "term": "Twitching",
      "count": 452
    },
    {
      "term": "Hypersalivation",
      "count": 451
    },
    {
      "term": "Falling",
      "count": 442
    },
    {
      "term": "Underdose",
      "count": 421
    },
    {
      "term": "Disorientation",
      "count": 418
    },
    {
      "term": "Not drinking",
      "count": 418
    },
    {
      "term": "Trembling",
      "count": 418
    },
    {
      "term": "Neutrophilia",
      "count": 395
    },
    {
      "term": "Walking difficulty",
      "count": 392
    },
    {
      "term": "Head tremor",
      "count": 378
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 371
    },
    {
      "term": "Dry skin",
      "count": 369
    },
    {
      "term": "Polydipsia",
      "count": 365
    },
    {
      "term": "Flaking skin",
      "count": 363
    },
    {
      "term": "Cough",
      "count": 362
    },
    {
      "term": "Foaming at the mouth",
      "count": 355
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 345
    },
    {
      "term": "Generalised itching",
      "count": 345
    },
    {
      "term": "Hyperactivity",
      "count": 344
    },
    {
      "term": "Agitation",
      "count": 340
    },
    {
      "term": "Pacing",
      "count": 335
    },
    {
      "term": "Hair loss NOS",
      "count": 323
    },
    {
      "term": "Skin lesion NOS",
      "count": 316
    },
    {
      "term": "Dehydration",
      "count": 309
    },
    {
      "term": "Lateral recumbency",
      "count": 307
    },
    {
      "term": "Rash",
      "count": 307
    },
    {
      "term": "Stiffness NOS",
      "count": 304
    },
    {
      "term": "Unable to stand",
      "count": 302
    },
    {
      "term": "Self trauma",
      "count": 297
    },
    {
      "term": "Urinary incontinence",
      "count": 287
    },
    {
      "term": "Pain NOS",
      "count": 280
    },
    {
      "term": "Thrombocytopenia",
      "count": 274
    },
    {
      "term": "Hyperglycaemia",
      "count": 273
    },
    {
      "term": "Aggression",
      "count": 261
    },
    {
      "term": "Hyperphosphataemia",
      "count": 261
    },
    {
      "term": "Pica NOS",
      "count": 261
    },
    {
      "term": "Anaemia NOS",
      "count": 260
    },
    {
      "term": "Elevated creatinine",
      "count": 250
    },
    {
      "term": "Systemic disorder NOS",
      "count": 248
    },
    {
      "term": "Weakness",
      "count": 247
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 243
    },
    {
      "term": "Inappropriate defecation",
      "count": 242
    },
    {
      "term": "Licking",
      "count": 242
    },
    {
      "term": "Pale mucous membrane",
      "count": 240
    },
    {
      "term": "Monocytosis",
      "count": 237
    },
    {
      "term": "Nausea",
      "count": 236
    }
  ]
}