{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 281
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 186
    },
    {
      "term": "Death",
      "count": 178
    },
    {
      "term": "Diarrhoea",
      "count": 127
    },
    {
      "term": "Anorexia",
      "count": 126
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 122
    },
    {
      "term": "Death by euthanasia",
      "count": 119
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 96
    },
    {
      "term": "Bradycardia",
      "count": 95
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 95
    },
    {
      "term": "Seizure NOS",
      "count": 92
    },
    {
      "term": "Emesis",
      "count": 84
    },
    {
      "term": "Vocalisation",
      "count": 83
    },
    {
      "term": "Ataxia",
      "count": 72
    },
    {
      "term": "Tachycardia",
      "count": 69
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 68
    },
    {
      "term": "Not eating",
      "count": 68
    },
    {
      "term": "Cardiac arrest",
      "count": 67
    },
    {
      "term": "Panting",
      "count": 67
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 62
    },
    {
      "term": "Pale mucous membrane",
      "count": 62
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 61
    },
    {
      "term": "Elevated total bilirubin",
      "count": 60
    },
    {
      "term": "Injection site swelling",
      "count": 60
    },
    {
      "term": "Weight loss",
      "count": 59
    },
    {
      "term": "Decreased appetite",
      "count": 58
    },
    {
      "term": "Hypothermia",
      "count": 56
    },
    {
      "term": "Elevated creatinine",
      "count": 55
    },
    {
      "term": "Sedation",
      "count": 54
    },
    {
      "term": "Fever",
      "count": 52
    },
    {
      "term": "Sedation prolonged",
      "count": 52
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 51
    },
    {
      "term": "Anxiety",
      "count": 50
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 50
    },
    {
      "term": "Leucocytosis NOS",
      "count": 49
    },
    {
      "term": "Apnoea",
      "count": 46
    },
    {
      "term": "Anaphylaxis",
      "count": 45
    },
    {
      "term": "Anaemia NOS",
      "count": 44
    },
    {
      "term": "Dehydration",
      "count": 44
    },
    {
      "term": "Depression",
      "count": 43
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 43
    },
    {
      "term": "Bloody diarrhoea",
      "count": 42
    },
    {
      "term": "Hypotension",
      "count": 42
    },
    {
      "term": "Hyperphosphataemia",
      "count": 41
    },
    {
      "term": "Pain NOS",
      "count": 41
    },
    {
      "term": "Neutrophilia",
      "count": 40
    },
    {
      "term": "Cyanosis",
      "count": 39
    },
    {
      "term": "Inappetence",
      "count": 39
    },
    {
      "term": "Hypersalivation",
      "count": 38
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 35
    },
    {
      "term": "Recovery prolonged",
      "count": 35
    },
    {
      "term": "Cough",
      "count": 33
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 32
    },
    {
      "term": "Elevated liver enzymes",
      "count": 32
    },
    {
      "term": "Thrombocytopenia",
      "count": 32
    },
    {
      "term": "Weakness",
      "count": 32
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 31
    },
    {
      "term": "Polydipsia",
      "count": 31
    },
    {
      "term": "Restlessness",
      "count": 31
    },
    {
      "term": "Dyspnoea",
      "count": 30
    },
    {
      "term": "Abnormal breathing",
      "count": 29
    },
    {
      "term": "Injection site pain",
      "count": 29
    },
    {
      "term": "Shaking",
      "count": 28
    },
    {
      "term": "Tachypnoea",
      "count": 28
    },
    {
      "term": "INEFFECTIVE, SEDATION",
      "count": 27
    },
    {
      "term": "Lateral recumbency",
      "count": 27
    },
    {
      "term": "INEFFECTIVE, ANESTHESIA",
      "count": 26
    },
    {
      "term": "Tremor",
      "count": 26
    },
    {
      "term": "Twitching",
      "count": 25
    },
    {
      "term": "Hypoproteinaemia",
      "count": 24
    },
    {
      "term": "Icterus",
      "count": 24
    },
    {
      "term": "Monocytosis",
      "count": 24
    },
    {
      "term": "Not drinking",
      "count": 24
    },
    {
      "term": "Unrelated death",
      "count": 24
    },
    {
      "term": "Abdominal pain",
      "count": 23
    },
    {
      "term": "Drooling",
      "count": 23
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 23
    },
    {
      "term": "Hyperglycaemia",
      "count": 23
    },
    {
      "term": "Nystagmus",
      "count": 23
    },
    {
      "term": "Polyuria",
      "count": 23
    },
    {
      "term": "Collapse NOS (see also 'Cardio-vascular' and 'Neurological disorders')",
      "count": 22
    },
    {
      "term": "Disorientation",
      "count": 22
    },
    {
      "term": "Agitation",
      "count": 21
    },
    {
      "term": "Low platelet count",
      "count": 21
    },
    {
      "term": "Neutropenia",
      "count": 21
    },
    {
      "term": "Respiratory arrest",
      "count": 21
    },
    {
      "term": "Skin lesion NOS",
      "count": 21
    },
    {
      "term": "Emesis (multiple)",
      "count": 20
    },
    {
      "term": "Loose stool",
      "count": 20
    },
    {
      "term": "Pruritus",
      "count": 20
    },
    {
      "term": "Weight gain",
      "count": 20
    },
    {
      "term": "Adipsia",
      "count": 19
    },
    {
      "term": "Aggression",
      "count": 19
    },
    {
      "term": "Elevated gamma-glutamyl transferase (GGT)",
      "count": 19
    },
    {
      "term": "Eye disorder NOS (for photophobia see 'neurological')",
      "count": 19
    },
    {
      "term": "Hyperactivity",
      "count": 19
    },
    {
      "term": "Regurgitation",
      "count": 19
    },
    {
      "term": "Surgical site disorder",
      "count": 19
    },
    {
      "term": "Swelling NOS",
      "count": 19
    },
    {
      "term": "Walking difficulty",
      "count": 19
    }
  ]
}