{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 194265
    },
    {
      "term": "Diarrhoea",
      "count": 72215
    },
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 68979
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 65635
    },
    {
      "term": "Emesis",
      "count": 63623
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 52790
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 52053
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 49593
    },
    {
      "term": "Anorexia",
      "count": 45961
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 43645
    },
    {
      "term": "Depression",
      "count": 34408
    },
    {
      "term": "Seizure NOS",
      "count": 30728
    },
    {
      "term": "Death",
      "count": 28449
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 24741
    },
    {
      "term": "Ataxia",
      "count": 23651
    },
    {
      "term": "Death by euthanasia",
      "count": 22673
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 21575
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 20066
    },
    {
      "term": "Pruritus",
      "count": 18905
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 18804
    },
    {
      "term": "INEFFECTIVE, ASCARIDS NOS",
      "count": 18226
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 17585
    },
    {
      "term": "Emesis (multiple)",
      "count": 16850
    },
    {
      "term": "Weight loss",
      "count": 16663
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 16264
    },
    {
      "term": "Not eating",
      "count": 16142
    },
    {
      "term": "Accidental exposure",
      "count": 15314
    },
    {
      "term": "Decreased appetite",
      "count": 13995
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 13715
    },
    {
      "term": "Bloody diarrhoea",
      "count": 13529
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 13270
    },
    {
      "term": "Shaking",
      "count": 13155
    },
    {
      "term": "INEFFECTIVE, HOOKS",
      "count": 12987
    },
    {
      "term": "Polydipsia",
      "count": 12770
    },
    {
      "term": "Overdose",
      "count": 12572
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 12414
    },
    {
      "term": "Panting",
      "count": 12297
    },
    {
      "term": "Fever",
      "count": 12272
    },
    {
      "term": "Lack of efficacy (bacteria) - Borrelia",
      "count": 12002
    },
    {
      "term": "Cardiac disorder NOS",
      "count": 11260
    },
    {
      "term": "Convulsion",
      "count": 10864
    },
    {
      "term": "Trembling",
      "count": 10761
    },
    {
      "term": "Anaemia NOS",
      "count": 10433
    },
    {
      "term": "Leucocytosis NOS",
      "count": 10402
    },
    {
      "term": "Elevated creatinine",
      "count": 10298
    },
    {
      "term": "Polyuria",
      "count": 9881
    },
    {
      "term": "Underdose",
      "count": 9658
    },
    {
      "term": "Vocalisation",
      "count": 9557
    },
    {
      "term": "Itching",
      "count": 9117
    },
    {
      "term": "Loose stool",
      "count": 9036
    },
    {
      "term": "Elevated total bilirubin",
      "count": 8958
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 8885
    },
    {
      "term": "Weakness",
      "count": 8764
    },
    {
      "term": "Anaphylaxis",
      "count": 8658
    },
    {
      "term": "Hypersalivation",
      "count": 8612
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 8438
    },
    {
      "term": "Restlessness",
      "count": 7981
    },
    {
      "term": "Cough",
      "count": 7763
    },
    {
      "term": "Elevated liver enzymes",
      "count": 7635
    },
    {
      "term": "Inappetence",
      "count": 7324
    },
    {
      "term": "Pale mucous membrane",
      "count": 7308
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 7281
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 7220
    },
    {
      "term": "Pain NOS",
      "count": 7095
    },
    {
      "term": "Tremor",
      "count": 7006
    },
    {
      "term": "Dehydration",
      "count": 6985
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 6881
    },
    {
      "term": "Thrombocytopenia",
      "count": 6620
    },
    {
      "term": "Deafness",
      "count": 6388
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 6382
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 6129
    },
    {
      "term": "Weight gain",
      "count": 6054
    },
    {
      "term": "Lack of efficacy (tick)",
      "count": 5999
    },
    {
      "term": "Hyperactivity",
      "count": 5895
    },
    {
      "term": "Neutrophilia",
      "count": 5804
    },
    {
      "term": "Urinary incontinence",
      "count": 5714
    },
    {
      "term": "Drooling",
      "count": 5566
    },
    {
      "term": "UNPALATABLE",
      "count": 5562
    },
    {
      "term": "Hypoalbuminaemia",
      "count": 5530
    },
    {
      "term": "Hyperphosphataemia",
      "count": 5502
    },
    {
      "term": "Abnormal ultrasound finding",
      "count": 5245
    },
    {
      "term": "Injection site swelling",
      "count": 5168
    },
    {
      "term": "Scratching",
      "count": 5070
    },
    {
      "term": "Tachycardia",
      "count": 5070
    },
    {
      "term": "Anxiety",
      "count": 5035
    },
    {
      "term": "Twitching",
      "count": 5000
    },
    {
      "term": "Hyperglycaemia",
      "count": 4944
    },
    {
      "term": "No sign",
      "count": 4917
    },
    {
      "term": "Dyspnoea",
      "count": 4888
    },
    {
      "term": "Urticaria",
      "count": 4840
    },
    {
      "term": "Icterus",
      "count": 4741
    },
    {
      "term": "Inappropriate urination",
      "count": 4711
    },
    {
      "term": "Polypnoea",
      "count": 4708
    },
    {
      "term": "Disorientation",
      "count": 4707
    },
    {
      "term": "Elevated aspartate aminotransferase (AST)",
      "count": 4705
    },
    {
      "term": "Skin disorders NOS",
      "count": 4689
    },
    {
      "term": "Not drinking",
      "count": 4601
    },
    {
      "term": "Urinary tract infection",
      "count": 4471
    },
    {
      "term": "Reluctant to move",
      "count": 4468
    },
    {
      "term": "Blood in vomit",
      "count": 4434
    }
  ]
}