{
  "meta": {
    "disclaimer": "Do not rely on openFDA to make decisions regarding medical care. While we make every effort to ensure that data is accurate, you should assume all results are unvalidated. We may limit or otherwise restrict your access to the API in line with our Terms of Service.",
    "terms": "https://open.fda.gov/terms/",
    "license": "https://open.fda.gov/license/",
    "last_updated": "2026-07-02"
  },
  "results": [
    {
      "term": "Vomiting",
      "count": 213498
    },
    {
      "term": "Diarrhoea",
      "count": 82046
    },
    {
      "term": "Lethargy (see also Central nervous system depression in 'Neurological')",
      "count": 76422
    },
    {
      "term": "Emesis",
      "count": 69445
    },
    {
      "term": "INEFFECTIVE, HEARTWORM LARVAE",
      "count": 69276
    },
    {
      "term": "Lack of efficacy (ectoparasite) - flea",
      "count": 63352
    },
    {
      "term": "Anorexia",
      "count": 59483
    },
    {
      "term": "Lack of efficacy - NOS",
      "count": 56125
    },
    {
      "term": "Lack of efficacy (endoparasite) - heartworm",
      "count": 52942
    },
    {
      "term": "Death",
      "count": 50961
    },
    {
      "term": "Lack of efficacy (endoparasite) - hookworm",
      "count": 49844
    },
    {
      "term": "Depression",
      "count": 42388
    },
    {
      "term": "Seizure NOS",
      "count": 33461
    },
    {
      "term": "Ataxia",
      "count": 31906
    },
    {
      "term": "Accidental exposure",
      "count": 31046
    },
    {
      "term": "Death by euthanasia",
      "count": 29803
    },
    {
      "term": "UNPALATABLE",
      "count": 28241
    },
    {
      "term": "Elevated alanine aminotransferase (ALT)",
      "count": 26969
    },
    {
      "term": "Behavioural disorder NOS",
      "count": 26442
    },
    {
      "term": "Pruritus",
      "count": 24464
    },
    {
      "term": "Weight loss",
      "count": 24015
    },
    {
      "term": "Elevated serum alkaline phosphatase (SAP)",
      "count": 22104
    },
    {
      "term": "Digestive tract disorder NOS",
      "count": 21171
    },
    {
      "term": "Not eating",
      "count": 21012
    },
    {
      "term": "Other abnormal test result NOS",
      "count": 20881
    },
    {
      "term": "Tablets, Abnormal",
      "count": 19589
    },
    {
      "term": "Emesis (multiple)",
      "count": 19169
    },
    {
      "term": "INEFFECTIVE, ASCARIDS NOS",
      "count": 19031
    },
    {
      "term": "Decreased appetite",
      "count": 17847
    },
    {
      "term": "Fever",
      "count": 17757
    },
    {
      "term": "Elevated blood urea nitrogen (BUN)",
      "count": 17527
    },
    {
      "term": "Lack of efficacy (ectoparasite) - tick NOS",
      "count": 17092
    },
    {
      "term": "Lethargy (see also Central nervous system depression in Neurological)",
      "count": 16998
    },
    {
      "term": "Hypersalivation",
      "count": 15873
    },
    {
      "term": "Panting",
      "count": 15139
    },
    {
      "term": "Containers, Damaged",
      "count": 14472
    },
    {
      "term": "Shaking",
      "count": 14416
    },
    {
      "term": "Overdose",
      "count": 14310
    },
    {
      "term": "Bloody diarrhoea",
      "count": 14286
    },
    {
      "term": "Polydipsia",
      "count": 14258
    },
    {
      "term": "Vocalisation",
      "count": 14108
    },
    {
      "term": "Lack of efficacy (endoparasite) - roundworm NOS",
      "count": 13976
    },
    {
      "term": "Elevated creatinine",
      "count": 13554
    },
    {
      "term": "INEFFECTIVE, HOOKS",
      "count": 13040
    },
    {
      "term": "Anaemia NOS",
      "count": 12846
    },
    {
      "term": "Convulsion",
      "count": 12721
    },
    {
      "term": "Trembling",
      "count": 12544
    },
    {
      "term": "Lack of efficacy (bacteria) - Borrelia",
      "count": 12009
    },
    {
      "term": "Leucocytosis NOS",
      "count": 11935
    },
    {
      "term": "Cardiac disorder NOS",
      "count": 11767
    },
    {
      "term": "No sign",
      "count": 11330
    },
    {
      "term": "Anaphylaxis",
      "count": 11302
    },
    {
      "term": "Lack of efficacy (bacteria) - NOS",
      "count": 11076
    },
    {
      "term": "Polyuria",
      "count": 11054
    },
    {
      "term": "Underdose",
      "count": 11006
    },
    {
      "term": "Hyperactivity",
      "count": 10837
    },
    {
      "term": "Color, Abnormal",
      "count": 10756
    },
    {
      "term": "Itching",
      "count": 10748
    },
    {
      "term": "Weakness",
      "count": 10661
    },
    {
      "term": "Underfilling, Package",
      "count": 10640
    },
    {
      "term": "Loose stool",
      "count": 10354
    },
    {
      "term": "Product problem",
      "count": 10340
    },
    {
      "term": "Unclassifiable adverse event",
      "count": 10311
    },
    {
      "term": "Elevated total bilirubin",
      "count": 10274
    },
    {
      "term": "Dehydration",
      "count": 10231
    },
    {
      "term": "Uncoded sign",
      "count": 10161
    },
    {
      "term": "Application site alopecia",
      "count": 10078
    },
    {
      "term": "Abnormal radiograph finding",
      "count": 9991
    },
    {
      "term": "Product Defect, General",
      "count": 9317
    },
    {
      "term": "Restlessness",
      "count": 9243
    },
    {
      "term": "Inappetence",
      "count": 9095
    },
    {
      "term": "Lack of efficacy (endoparasite) - whipworm",
      "count": 8930
    },
    {
      "term": "Lack of efficacy (endoparasite) - tapeworm",
      "count": 8900
    },
    {
      "term": "Cough",
      "count": 8798
    },
    {
      "term": "Pain NOS",
      "count": 8692
    },
    {
      "term": "Pale mucous membrane",
      "count": 8433
    },
    {
      "term": "Injection site swelling",
      "count": 8413
    },
    {
      "term": "Lack of efficacy (flea)",
      "count": 8324
    },
    {
      "term": "Elevated liver enzymes",
      "count": 8231
    },
    {
      "term": "Application site hair loss",
      "count": 8119
    },
    {
      "term": "Tremor",
      "count": 8028
    },
    {
      "term": "Drooling",
      "count": 7944
    },
    {
      "term": "Hyperglycaemia",
      "count": 7864
    },
    {
      "term": "Dyspnoea",
      "count": 7608
    },
    {
      "term": "Thrombocytopenia",
      "count": 7338
    },
    {
      "term": "Containers, Leaking",
      "count": 7289
    },
    {
      "term": "Underfilling, Tubes",
      "count": 7259
    },
    {
      "term": "Scratching",
      "count": 7142
    },
    {
      "term": "Recumbency",
      "count": 7090
    },
    {
      "term": "Hyperphosphataemia",
      "count": 7003
    },
    {
      "term": "Twitching",
      "count": 6999
    },
    {
      "term": "Neutrophilia",
      "count": 6910
    },
    {
      "term": "Tachycardia",
      "count": 6765
    },
    {
      "term": "Facial swelling (see also 'Skin')",
      "count": 6682
    },
    {
      "term": "Deafness",
      "count": 6661
    },
    {
      "term": "Weight gain",
      "count": 6660
    },
    {
      "term": "Hives (see also 'Skin')",
      "count": 6569
    },
    {
      "term": "Underfilling, Container",
      "count": 6245
    },
    {
      "term": "Not drinking",
      "count": 6227
    },
    {
      "term": "Abdominal pain",
      "count": 6216
    }
  ]
}